Publication

Ageing, microbes and health

Paul W. O'Toole · DOI: 10.1111/1751-7915.14477

The human gut microbiome is a modifier of the risk for many non-communicable diseases throughout the lifespan. In ageing, the effect of the microbiome appears to be more pronounced because of the lower physiological reserve.

Microbial metabolites and other bioactive products act upon some of the key physiological processes involved in the Hallmarks of Ageing. Dietary interventions that delay age-related change in the microbiome have also led to delayed onset of ageing-related health loss, and improved levels of cognitive function, inflammatory status and frailty.

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Why this matters for Microb-AI-ome

This publication highlights the importance of the gut microbiome in human health and disease risk across the lifespan. It supports the broader scientific rationale behind microbiome-based approaches for prevention, prediction and personalised healthcare, which are central to Microb-AI-ome’s work on AI-supported colorectal cancer screening.