Scientific publication

Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus

Rachel MacCann, Junhui Li, Alejandro Abner Garcia Leon, Riya Negi, Dana Alalwan, Willard Tinago, Padraig McGettrick, Aoife G. Cotter, Alan Landay, Caroline Sabin, Paul W. O’Toole & colleagues · The Journal of Infectious Diseases · April 2025

This study investigates the relationship between gut microbiome composition, systemic inflammation and cardiovascular disease risk in people living with HIV.

The researchers identified significant differences in gut microbiome diversity associated with HIV status, including depletion of beneficial short-chain fatty acid–producing bacteria linked to increased inflammation and cardiovascular risk markers.

The findings further support the growing evidence that microbiome alterations influence chronic inflammation, metabolic health and disease risk, highlighting the importance of microbiome-based approaches in precision medicine and preventive healthcare.

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Why this matters for Microb-AI-ome

Understanding how gut microbiome alterations contribute to systemic inflammation and disease risk is highly relevant for Microb-AI-ome’s research objectives. This publication highlights the importance of microbiome-derived biomarkers and microbiome-associated inflammatory profiles in precision medicine approaches, supporting the broader development of AI-driven microbiome analysis for disease prediction and prevention.